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PRF （Platelet-RichFibrin，富血小板纤维蛋白）它是 2000年报道的第二代富血小板血液制品，它的制备方法是通过全血不添加任何抗凝剂立刻一次离心而获得的高浓度血小板纤维蛋白凝胶。目的：注射型富血小板纤维蛋白 (injectable-platelet-rich fibrin, i-PRF)是一种血小板浓缩物，其内含有丰富的生长因子且具有良好的生物相容性，可作为支架材料用于组织再生。为解决牙周组织再生中生长因子释放不足和细胞迁移效率低的问题，研究人员通过系统评价分析可注射富血小板纤维蛋白 (i-PRF)的疗效。

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可注射型富血小板纤维蛋白（iPRF）是一种具有流动性的新型血小板浓缩物（PC）。 iPRF在传统富血小板纤维蛋白（PRF）制备方法的基础上，改变了离心参数和收集方式，因此具有更良好的生物学性能。. I-PRF是一种通过低速离心获得的生物活性剂，它可以刺激组织再生。高浓度的 I-PRF 可能会刺激多种生长因子的分泌并引发成纤维细胞迁移。 I-PRF 通常用于再生治疗，但它也存在一些问题。目的最近的一些研究表明，遵循标准的可注射富含血小板的纤维蛋白（i-PRF）方案，血小板和白细胞浓度仅能获得少量改善。